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IV Fluids, I.V. solutions, Intravenous fluids, Normal Saline (NS, 0.9NaCl, or NSS), Lactated Ringers (LR, Ringers Lactate, or RL), Dextrose 5%, Normal Saline (Half Normal Saline, 0.45NaCl, .45NS), IV Fluids & Dialysis products - LVP/SVP Volume Parenteral

 

I V Fluids

Intravenous therapy (IV) is therapy that delivers fluids directly into a vein. The intravenous route of administration can be used both for injections, using a syringe at higher pressures; as well as for infusions, typically using only the pressure supplied by gravity. Intravenous infusions are commonly referred to as drips.

The intravenous route is the fastest way to deliver medications and fluid replacement throughout the body, because they are introduced directly into the circulation. Intravenous therapy may be used for fluid volume replacement, to correct electrolyte imbalances, to deliver medications, and for blood transfusions.

Infusion therapy as a basic toll of modern medical care enables the physician to restore and stabilize homeostasis states quickly and completely. In nursing homes and hospital where patients are suffering from acute dehydration or considerable debilitating conditions, the intra venous fluids are used as I.V. drips. The basic function of I.V. fluids is to replenish the body fluids. Although there are number of I.V. fluids, but generally three types of I.V. fluids are used in hospitals as I.V. drips. 1. Dextrose injection fluid. 2. Dextrose and sodium chloride injection fluid. 3. Sodium Chloride injection solution (Saline solution). Dextrose solution is used during postoperative period when sodium extraction of 10-15% are used as diuretic for increasing in urine flow. Saline solution is used when large amount of sodium has been lost by vomiting or by gastric or intestinal duodenal aspiration or through an alimentary fistula. Dextrose monohydrate is used as supplement to cow’s milk in part of feeding. Hypertonic dextrose solution (25-50%) is in medical treatment partly because they are believed to strengthen heart muscles. Hypertonic solutions are used in intravenous injection to relieve intractable pressure in-patient with hydrocephalus and meningitis. The drug industry has now achieved an impressive growth during the last four decades of planning and development. These I.V. fluids are the best alternative, which can yield sudden result in the health of a Patient by replenishing the body fluids.

Intravenous solutions have evolved with technologies and designs improving their overall functionalities. There are several combinations of packaged intravenous products that have come up in recent years. Manufacturers are introducing IV fluids and compounds that can be mixed with other liquid medicines and solutions for IV administration. The aforementioned factors will continue to drive the global intravenous (IV) solution market.  Some of the factors that are having positive impact on the growth of the intravenous (IV) solution market include increased prevalence of chronic disorders and growing popularity of IV led treatments and therapies intended towards curing cance.

Uses and Applications

There are main ranges of application of highly specialized intravenous infusion solutions:

• Treatment of discarded water and electrolyte metabolism, especially in severe cases.

• Therapy of acid base in balances.

• The volume substitution and volume replacement in surgery of accident victim suffering blood loss.

• Paratral nutrition for severally ill and post-operative patients.

Aqueous isotonic injection (5%) of dextrose is given as intravenous injections to increase the column of circulating blood in the shocks and hemorrhages and to counteract dehydration. When it is desired to replace excessive salt loss also glucose is injected along with sodium chloride. Intravenous fluids can also be used as a route of medication administration. If a doctor wants to delI.V.er a small amount of medication over an extended period of time, it can be dissolved in a bag of intravenous fluids and set on an infusion pump which delivers the medicated fluid directly into the blood.

They are also commonly used to assist with surgical recovery; people who receive fluids after surgery tend to experience better recovery than people who do not.

Global Intravenous Solutions Market Trends:

Over the past few years, the prevalence of hectic work schedules and unhealthy lifestyles has increased across the globe. The consequent decline in physical activity and proper nutrition has led to a rise in the incidences of chronic diseases, which in turn has boosted the demand for intravenous solutions. Besides, there has been significant growth in the production of IV fluids, particularly in developed countries. For instance, it was reported that due to the shortage of IV saline, the US Food and Drug Administration (FDA) and other market. The intravenous fluid bags market size will grow at a CAGR of 6% at an incremental growth of $ 667.51 MN during 2020-2024.

The increasing prevalence of chronic diseases such as the rise of cholera and growing acceptance of vitamin c intravenous for colorectal cancer are the major drivers propelling market growth. However, the presence of stringent government regulations, rising continuous demand for IV solutions in the US, and increasing vitamin C intravenous therapy prices constrain the growth of the market.

The rising number of surgeries, the need for a faster route of drug administration, growing preference for single-dose administration of vaccines and drugs, and an increase in local manufacturing is expected to drive the market for LVP. Parenteral route of administration helps provide an accurate dose of medication as the majority of the drug is directly absorbed in circulation, bypassing the gastrointestinal tract.

The drug serum level increases rapidly through parenteral administration. For instance, postoperative parenteral nutrition induces a substantial increase in serum leptin within six hours and helps reach a rise of more than four folds within 14 hours. Moreover, parenteral administration of ascorbate (Vitamin C) decreases the growth rate of murine hepatoma. However, oral administration of the same dosage does not exhibit similar anti-tumoral effects.

Advantages of BFS Technology:

Blow-fill-seal technology enables the manufacture of preservative-free single-unit doses. PreservatI.V.es are recognized as potentially harmful to the sensitive mucosae of the eyes, nose, and lungs, so this is an enormous benefit to sensitive patients. Another advantage of unit-doses is that they ensure that the patient takes the correct amount of product, especially when dealing with highly potent compounds, i.e. those therapeutically active at a low concentration.

Sterile unit-doses are portable and easy to use individually, excellent properties for today’s active lifestyles. Blow-fill-seal (BFS) single doses are an ideal solution for use in ophthalmology, respiratory diseases, rhinology, and antisepsis and wound care. Blow-fill-seal technology reduces personnel intervention making it a more robust method for the aseptic preparation of sterile pharmaceuticals. BFS is used for the filling of vials for parenteral preparations and infusions, eye drops, and inhalation products. Generally the plastic containers are made up of polyethylene and polypropylene. Polypropylene is more commonly used to form containers which are further sterilized by autoclaving as polypropylene has greater thermo stability.

Blow Fill and Seal technology is mainly used for pharmaceutical solutions. The examples of pharmaceutical solutions that can be packaged are injectable solutions, antibiotics, ophthalmological drops, suspensions, infusion solutions, solutions for dialysis, solutions for irrigation and solutions for hemofiltration. The basic concept of BFS is that a container is formed, filled, and sealed in a continuous process without human intervention, in a sterile enclosed area inside a machine. Thus this technology can be used to aseptically manufacture sterile pharmaceutical liquid dosage forms.

The process is multi-stepped: first, pharmaceutical-grade plastic resin is vertically heat extruded through a circular throat to form a hanging tube called the parison. This extruded tube is then enclosed within a two-part mould, and the tube is cut above the mould. The mould is transferred to the filling zone, or sterile filling space, where filling needles (mandrels) are lowered and used to inflate the plastic to form the container within the mould. Following the formation of the container, the mandrel is used to fill the container with liquid. Following filling the mandrels are retracted and a secondary top mould seals the container. All actions take place inside a sterile shrouded chamber inside the machine. The product is then discharged to a non-sterile area for labeling, packaging and distribution. The process begins with the Extrusion of plastic granules in the form of a hot hollow pipe of molten plastic called a parison.

The following step is the Blow molding of the container from the plastic granule. The parison is closed between the mould, and the container gets formed either by blowing sterile compressed air or by vacuum or by using vacuum as well as blowing. The container assumes the shape of the cavity in the mould. The container thus produced is open from the top and in its top part, the plastic is still hot and in molten state until the subsequent steps of filling and container sealing.

Features:

1. 100% film utilization: No waste edge between bags, reducing both material and energy consumption.

2. Special I.V. bag design: each bag saves 10mm film than others.

3. Reliable heating and welding system: Leakage rate less than 0.03%.

4. Quick changeover: 0.5-1 hour to switch from one size to another.

5. Stable transmission system: only needs 1 control system, 1 HMI and 1 operator.

6. Safe filling nozzle: No solution overflows, no particles generation.

7. Auto faulty rejection system detected by the machine.

8. Production line length is reduced by 1/3, both workshop and air conditioning and cleaning area are reduced by 1/3, greatly reducing the initial investment and future running cost.

9. Simple structure, more stable and reliable performance.

 

 

 

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GLUCOSE SALINE - Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities, Cost and Revenue, Plant Economic

Dextrose is a carbohydrate caloric agent. Glucose, also known as dextrose, is a simple sugar that can be found in nature and are chemically identical. Dextrose is simply in lay terms sugar water and is generally used in those patients who have a very low blood glucose level or are unable to eat for some reason. It is a short term treatment generally. D5NS (Dextrose 5% in normal saline) is hypertonic, meaning it has a higher solute concentration than tissues, so it can be used to help draw fluids out of oedematous (fluid-swollen) tissues. Dextrose (glucose) 5% and normal saline (sodium chloride or common table salt 8.5 grams per 100 ml of distilled water), have the same tonicity or concentration of the rest of the body fluids, that is, they will do no harm to the rest of the fluids of the body whereas Saline or 9%NS IV solution is used as the universal fluid replacement in dehydrated individuals, it is the same composition as the body's normal fluid and most IV medications can safely be mixed with or push through saline. Dosage of dextrose depends on the age, weight, clinical condition, and fluid, electrolyte, and acid-base balance of the patient. Dextrose is readily metabolized; it increases blood glucose concentrations and provides calories. Dextrose may decrease body protein and nitrogen losses, promote glycogen deposition, and decrease or prevent ketosis if sufficient doses are given. Since dextrose is usually metabolized to carbon dioxide and water, administration of a solution of dextrose and water is equivalent to providing the same volume of free water. Following oral administration, dextrose, a monosaccharide, is rapidly absorbed from the small intestine principally by an active mechanism. In patients with hypoglycemia, increases in blood glucose concentration usually occur within 10–20 minutes and peak at about 40 minutes after oral administration of dextrose. In medicine, saline (also saline solution) is a general term referring to a sterile solution of sodium chloride (NaCl, more commonly known as salt) in water but is only sterile when it is to be placed intravenously; otherwise, a saline solution is a salt water solution. Thus, an intravenous infusion, a saline solution is typically mixed with dextrose or glucose to reduce any complications from infusing saline solution and to reduce the amount of sodium circulating through the blood stream. This works particularly well as a water and nutrient supplement to sustain hospitalized patients who are unable to eat or drink or who have suffered dehydration from severe vomiting or diarrhea. In present era, people are becoming very health conscious as the infection through air, water, food is prevailing across the country to the maximum. As hospitals are increasing day by day, doctors also prefer to use distilled water ampoules. There are several in organized and private sectors are engaged in the manufacturing of different grade dextrose saline solution. The demand growth is about 5% in each and every year. The entire demand gap is fulfilled by the domestic manufacturers. There is scope of dextrose saline bottle. New entrepreneur may launch in this field will be successful. Few Indian Major Players are as under: Gulshan Polyols Ltd. Kamala Sugar Mills Ltd. Origin Agrostar Ltd. Rai Agro Inds. Ltd. Sanjeevanee Pharmaceuticals Ltd. Santosh Starch Ltd. Sukhjit Starch & Chemicals Ltd. Unique Sugars Ltd. Universal Starch-Chem Allied Ltd.
Plant capacity: 3600 Thousand Bottles Each Bottles 500 ml/AnnumPlant & machinery: 66 Lakhs
Working capital: -T.C.I: Cost of Project : 153 Lakhs
Return: 42.00%Break even: 59.00%
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GOOD FUTURE PROSPECTS FOR MAIZE PROCESSING & ITS ALLIED PRODUCTS (STARCH, LIQUID GLUCOSE, DEXTROSE MONOHYDRATE, DEXTROSE ANYHDROUS, SORBITOL AND VITAMIN C)

Maize (Zea mays L) is one of the most important cereals of the world and provides more human food than any other cereal. Starch is a group of polysaccharides, composed of glucopyranose units joined together by glucosidric linkages. It conforms to the molecular formula, (C6 H10O5)n, where n varies from a few hundred to over one million. Starch is found as the reserve carbohydrate in various parts of plants and is enzymatically broken down to glucose to other carbohydrates according to the metabolic needs of the plants. Industrially, starch is broadly divided into two types viz., natural and modified. Natural starches also designated as unmodified starches or simply starches, are obtained from grains such as sorghum. Starch is also obtained from roots like potato, tapioca and arrowroot, and from the pith of the stems of certain palms such as sago. They are further classified into cereal starches and root starches. The characteristics of the natural starches are changed by chemical or enzymatic action and the products of these reactions are termed modified starches. This group includes dextrins, acid-modified starches, oxidized starches, starch esters, starch ethers, dialdehyde starches, and cationic starches. The roots of tapioca plant (manihot utilissima) forms one of the major sources of starch, ranking next to potato. The starch content of the plant varies between 12 and 33 per cent. The cereal starches, such as maize, wheat, rice and sorghum, are recovered by several processes, of which the wet milling is by far the most important. Starch is an absorbent for water. Starch and Glucose can be used in different end use industries such as in the manufacture of adhesives, sizing and finishing in textiles, thickening agents in gravies, custards, and confectioneries. Sizing papers, Cosmetics, explosives, reagent, face powders, indicators in domestic analysis, water soluble packaging films, book bindings fabrics, distilled liquors, malt sugar, cattle feed ingredient, rubber reinforcing resins etc. Starch in India is mainly used for cotton textile industry, paper and paper products, Biscuits and confectioneries and glucose and dextrose. Commercially glucose is produced from starch only and these two products are generally made in the same unit side by side. One tonnes of glucose needs 1.1 tonne of starch. About 90% of the liquid glucose produced in India is consumed by the confectionery industry. Liquid Glucose and Dextrose are the products of same origin, in liquid form and the late in powder form. Glucose powder (dextrose) is used an invalid food for pharmaceutical purposes. Aqueous isotonic solution (5%) of dextrose is given as intravenous infections to increase the volume of circulating blood shocks and hemorrhage and to counteract dehydration. Vitamin C is a strong monobasic acid and it is used as a powerful reducing agent in neutral and acidic solutions. It is also used medicine. It is an excellent nutritional agent. It is an antioxidant and a preservative in foodstuffs. It is used as a reducing agent in analytical chemistry. The ferric and calcium salts are available for biochemical research. It is also available as the sodium salt. Sorbitol is an organic chemical having varied end uses. It is edible non-crystalline, odorless white powder and having sweet cooling taste. It is highly soluble in water, and slightly in methyl alcohol. In the case of India, starch is being produced from Maize and tapioca. The units producing starch from maize are concentrated in large sector; and the units producing starch from tapioca are largely concentrated in the small-scale sector. There are many units as at present in the country producing starch from Maize and three units producing starch from Tapioca in the organized sector. The capacity for starch from Maize accounts for more than 80 per cent of the installed capacity in the organized sector. As against the organized sector, there are a number of units in the small and cottage sector producing starch mainly from tapioca. As regards glucose it is produced in solid as well as liquid form. The production of glucose is not possible in the small sector and therefore its production is not as widely spread as that of starch. Eight units manufacturing starch in the organized sector also produce liquid glucose simultaneously. The demand for liquid glucose depends mainly upon the growth of medicine, the pharmaceuticals, biscuits and confectionery industries. As such 80% of the total demand for liquid glucose is absorbed by drugs and pharmaceuticals, while only 20% is used in Biscuits, Confectioneries, toothpaste etc. There is a very good scope and ample space in this sector and new entrepreneurs should venture into this field. Capacity Maize Starch 30000 MT/Annum Liquid Glucose 600 MT/Annum Dextrose Monohydrate 3900 MT/Annum Dextrose Anhydrous 3000 MT/Annum Sorbitol 17100 MT/Annum Vitamin–C 150000 Kg/Annum
Plant capacity: -Plant & machinery: 780 Lakhs
Working capital: -T.C.I: Cost of Project : 2590 Lakhs
Return: 42.00%Break even: 56.00%
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Maize Starch & Liquid Glucose - Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities, Cost and Revenue

Starch is a group of polysaccharides, composed of glucopyranose units joined together by glucosidric linkages. It conforms to the molecular formula. Where a varies from a few hundred to over one million. Starch is found as the reserve carbohydrate in various parts of plants and is enzymetically broken down to glucose to other carbohydrates according to the metabolic needs of the plants. Starch has many industrial applications. These include (a) Textile Industry (b) Food Industry (c) Paper Industry (d) Pharmaceutical Industry (e) Manufacture of modified starch. Liquid Glucose produced in India is consumed by the confectionery industry. It is used also in textile printing and in biscuit and canning industries, tanning and tobacco curing. This is used in leather, textile, pharmaceutical and other industries. The history of starch industry dates back to early forties. There are few units at present in the country producing starch from maize and three units producing starch from Tapioca in the organized sector. There is bright market potential for maize starch and liquid glucose. New entrepreneurs can venture into this field. Few Indian Major Players are as under: Anil Products Ltd. Anil Starch Products Ltd. [Merged] Bharat Starch Inds. Ltd. [Merged] English Indian Clays Ltd. Gayatri Bioorganics Ltd. Gujarat Ambuja Exports Ltd. Gujarat Ambuja Proteins Ltd. [Merged] Gulshan Polyols Ltd. Indian Maize & Chemicals Ltd. International Bestfoods Ltd. [Merged] K G Gluco Biols Ltd. [Merged] Kamala Sugar Mills Ltd. Karnataka State Agro Corn Products Ltd. Laxmi Starch Ltd. Origin Agrostar Ltd. Pondicherry Agro Service & Inds. Corpn. Ltd. Rai Agro Inds. Ltd. Riddhi Siddhi Gluco Biols Ltd. Santosh Starch Ltd. Santosh Starch Products Ltd. Sayaji Industries Ltd. Sukhjit Starch & Chemicals Ltd. Tirupati Starch & Chemicals Ltd. Unique Sugars Ltd. Universal Starch-Chem Allied Ltd. Wockhardt Health Care Ltd. [Merged] Cost Estimation: Capacity : Maize Starch 22312 MT/Annum Liquid Glucose 8925 MT/Annum Germ (Bye Product) 1785 MT/Annum Fibre (Bye Product) 892 MT/Annum Steep Water (Bye Product) 2677 MT/Annum
Plant capacity: -Plant & machinery: 1477 Lakhs
Working capital: -T.C.I: Cost of Project : 2425 Lakhs
Return: 41.00%Break even: 44.00%
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I V (Intravenous)Fluid (FFS Technology)

Profile Intravenous fluids are fluids which are intended to be administered to a patient intravenously, directly through the circulatory system. These fluids must be sterile to protect patients from injury, and there are a number of different types available for use. Many companies manufacture packaged intravenous fluids, as well as products which can be mixed with sterile water to prepare a solution for intravenous administration. Intravenous fluids can be broken into two broad groups. Crystalloids such as saline solutions contain a solution of molecules which can dissolve in water. When crystalloids are administered, they tend to create low osmotic pressure, allowing fluid to move across the blood vessels, and this can be linked with edema. Colloids contain particles which are not soluble in water, and they create high osmotic pressure, attracting fluid into the blood vessels. Blood is an example of a commonly administered intravenous colloid. Application Intravenous fluids can also be used as a route of medication administration. If a doctor wants to deliver a small amount of medication over an extended period of time, it can be dissolved in a bag of intravenous fluids and set on an infusion pump which delivers the medicated fluid directly into the blood. They are also commonly used to assist with surgical recovery; people who receive fluids after surgery tend to experience better recovery than people who do not. Types of Fluids • Normal Saline • Half Normal Saline • Ringers Lactate • D5W • D5W + ½% NS • 2/3 + 1/3 • Normal Plasma Form, Fill & Seal (FFS) Technology It is also an economical solution providing an inline manufacturing of the bag from a side gusseted film roll as well as filling and sealing. An automatic and precise process, environmentally safe, and cost efficient FFS gusseted tubing is water & moisture resistant, and can also be made with vapor and oxygen barrier substrates. It is both extremely durable and 100% recyclable. Advantages of FFS Gusseted Tubing Moisture & water resistant, increasing your products shelf life and reducing product waste Made from a strong and durable 3-layer film containing only the highest quality polyethylene resins with excellent sealing characteristics Easy palletizing made possible due to the shape of the filled package 8-color print capability, including 4 color process print graphics over the entire surface front, back and inside gussets to provide an eye catching product Optional built in self venting back seam labyrinth valve Compatible with existing FFS packaging machinery. SUSTAINABILITY 100% Recyclable Elimination of particle dust, creating a clean, safe and healthy environment for bagging facilities, retailers and end-users alike Increased product life cycle due to extreme barrier protection and seal strength Reduced product rework due to broken bags: less additional production and packaging required, leading to less energy and resources consumed Fewer breakages compared to traditional packaging, reducing product loss Clean in-store product presentation. FFS offers cost savings over conventional aseptic processing in glass. Traditional parental filling and packaging requires 23 steps and individual machines for filling, stoppering and capping. In contrast, FFS requires one piece of automated machinery, and takes place in six seconds or less. Market Scenario World market growth is driven by population increases and constant up-scaling and sophistication of health care delivery. As part of this up scaling, IV infusion therapy is becoming increasingly important in overall health care treatment regimens as new developments in antibiotics and other medications used in areas such as chemotherapy, burn centers, and renal/peritoneal dialysis centers favor intravenous use and application. The economic advantages of producing IV solutions locally emerging and medically in developing nations can result in an extremely short return on initial investment. Demand for IV solutions is so great that should production exceed local demand. Opportunities for national and export sales are unlimited in the foreseeable future.
Plant capacity: 9000000 No.s of Bottles (Each bottle: 1000ml)Plant & machinery: 850 Lakhs
Working capital: -T.C.I: Cost of project: 1351 Lakhs
Return: 43.00%Break even: 49.00%
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IV (intravenous) Fluids [Form Fill Seal (FFS) Technology] - Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Plant Layout

Intravenous fluids are fluids which are intended to be administered to a patient intravenously, directly through the circulatory system. These fluids must be sterile to protect patients from injury, and there are a number of different types available for use. Many companies manufacture packaged intravenous fluids, as well as products which can be mixed with sterile water to prepare a solution for intravenous administration. Fluids are given when someones body fluid volume falls. There are a number of things which can cause a drop in fluid volume. Vomiting and diarrhea are a classic example, which is why people are encouraged to drink fluids when they are sick, to keep their fluid volume stable. Another cause is blood loss, which causes problems both because people lose blood products, and because they experience a loss in fluid volume. Electrolyte levels in the blood can also become unstable as a result of rapid changes in fluid volume, in which case intravenous fluids can be used to restore the balance. Uses and Application There are four main ranges of application of highly specialized intravenous infusion solutions: Aqueous isotonic injection (5%) of dextrose is given as intravenous injections to increase the column of circulating blood in the shocks and haemarrhages and to counteract dehydration. When it is desired to replace excessive salt loss also glucose is injected along with sodium chloride, Dextrose solution is used during postoperative period when sodium extraction is reduced, Dextrose solution with concentration of 10 to 15% are used as diuretic for increase in urine flow, Dextrose solution of 5% normal salinic are used for restoring fluid volume in circulation of an emergency as in accidents with haemarrhage. Market Survey Indias traditions in the science of health and healing go back to the halcyon days of Surushta, Vagbhatta and Charaka. Our system of medicine like Ayurveda was well established and schools and hospitals with treatises and instruction manuals were in wide use. I.V. fluid demand is normally linked to the number of hospital beds. Observations show that 18 bottles of I.V. fluids are consumed per bed per month in the country. The demand is estimated to increase at a rate of 9 to 12% per annum. The growth of I.V fluid manufacturing was faster than the growth rate of drugs. I.V fluids are the solutions applied directly to the vein of a patient who suffer from the weaknesses due to the deficiency of body fluids. These I.V. fluids are the best alternative, which can yield sudden result in the health of a patient by replenishing the body fluids.
Plant capacity: 9000000 Nos. Bottles/ Annum(Each 1000 ml. Bottles)Plant & machinery: 851 Lakhs
Working capital: -T.C.I: Cost of Project : 1251 Lakhs
Return: 43.00%Break even: 49.00%
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Dextrose Powder - Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities, Cost and Revenue, Plant Layout

Dextrose (or D-Glucose) is a simple hexose mono-saccharide sugar. It is the natural form of Glucose. Dextrose is offered at a very high grade of purity. Its empirical formula is C6H12O6. Dextrose is used as a source of energy to cultivate microorganisms and for fermentation studies. Dextrose is incorporated into many culture media formulae such as those employed in the selective isolation of enterobacteriaceae. Dextrose is obtained from starches or cellulose. The raw materials can be corn, rice potatoes or many other vegetables. Dextrose Monohydrate is the crystalline form of glucose it is a source of carbohydrate energy. Dextrose is commercially available in monohydrate or anhydrate form termed Dextrose Monohydrate or Dextrose Anhydrate respectively. Uses and Applications Dextrose can be used in food applications, pharmaceutical, chemical and animal feed. Dextrose is used in cold brines curing salts and meat maturing preparations. In dairy desserts dextrose can replace 10-15% of the sucrose without affecting flavor. In sauces it can be used to vary sweetness and taste perception. In ice cream, dextrose can lower the freezing point by twice the extent given by sucrose. It can be used in energy drinks being rapidly assimilated by micro organisms in the small intestine. It is also used as bulking agent and sweetener in powdered drinks. Due to its total ferment ability dextrose can be used as a priming agent in brewing. It is widely used in chewing gum as an enhancer of fruit flavors. In the production of tablets dextrose gives a fresh sensation because it dissolves pleasantly on the tongue. It provides excellent stable crunchiness with a pleasant cooling effect. Dextrose reduces sweetness while retaining energy value and glazing capacity. It is used as diluents for tablets and in rehydration salts to replenish water and mineral reserves. Dextrose can be used as a hydrophilic agent in the synthesis of biodegradable non-ionic surfactants. Dextrose is used also as a weak reducing agent in the dyestuff industry. Dextrose provides a highly assailable form of energy; it is a soluble carrier for special substance which requires to be diluted into the drinking water. Market Survey The demand for dextrin and dextrose is highly influenced by the growth of the manufacturing sectors mainly textiles, glass, printing ink food soft drink tanning tobacco and the like. The manufacturing sector has been growing by more than 6% in the past few years. Assuming the past trend will continue in the future, an annual average growth rate of 6% is applied to forecast the future demand by taking the current effective demand as a base. Starch and its derivatives have emerged as the most promising environment friendly ingredient over the years and offers varied application benefits in both food as well as non-food industries. There has been a steady increase in demand of starch in food & beverage industry due to high prices of sugar. Now, as Pharmaceutical industry is having a soaring business, so will be the dextrose business. Dextrose is used as energy providing ingredient to sick people. So the industries related producing dextrose will have a huge profitable business. Present Manufacturers Gujarat Ambuja Proteins Ltd. Indian Maize & Chemicals Ltd. K G Gluco Biols Ltd. [Merged] Kamala Sugar Mills Ltd. Origin Agrostar Ltd. Tirupati Starch & Chemicals Ltd. Unique Sugars Ltd. Wockhardt Health Care Ltd.
Plant capacity: 30 MT/ dayPlant & machinery: Rs.1336 Lakhs
Working capital: -T.C.I: Rs. 2429 Lakhs
Return: 35.00%Break even: 44.00%
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Saline and Dextrose Fluid (IV Fluid) BFS Technology

As part of the millennium development goals (MDGs), governments in the region have developed strategies directed at reducing the negative impact of diseases like HIV, Malaria or Tuberculosis on the society by 2015. The strategies include halting and reversing the spread of HIV/AIDS, reducing the level of malaria infection, and reducing prevalence and death rates associated with tuberculosis. Severe malaria results into high fever, which requires the use of Intravenous Fluids as the first line of treatment. However, due to limited local production and supply, the fluids are comparatively expensive compared to other developed world where they are affordable and readily available. In India, local monopolies and distributors that sell the fluids very costly import 98% of the IV Fluids. Faced with the current factual situation Govt. Oriented organization planned to establish Intravenous Project to locally produce and supply this very essential product to the healthcare sector as a noble contribution in improving healthcare services. The project expects to promote the common good in the Eastern Region, to reduce the current high level of deaths from 9-14% of in-patient visits in hospitals and health facilities. In medicine, saline (also saline solution) is a general phrase referring to a sterile solution of sodium chloride (NaCl, more commonly known as salt) in water, but is only sterile when it is to be placed parenterally (such as intravenously); otherwise, a saline solution is a salt water solution. The sterile solution is typically used for intravenous infusion, rinsing contact lenses, nasal irrigation, and often used to clean a new piercing. It is also a good medium to store an avulsed ("knocked out") tooth until it can be re-implanted by a dentist. Saline solutions are available in various formulations for different purposes. Salines are also used in cell biology, molecular biology, and biochemistry experiments. Uses & Applications There are four main ranges of application of highly specialized intravenous infusion solutions: • Treatment of discarded water and electrolyte metabolism, especially in severe cases. • Therapy of acid base in balances. • The volume substitution and volume replacement in surgery of accident victim suffering blood lose. • Paratrial nutrition for severally ill and post-operative patients. • Aqueous isotonic injection (5%) of dextrose is given as intravenous injections to increase the column of circulating blood in the shocks and hemorrhages and to counteract dehydration. Dextrose solution is used during post operative period when sodium extraction is reduced. • Dextrose solution with concentration of 10-15% is used as diuretic for increase in urine flow. • Dextrose solution of 5% normal salmic is used for restarting fluid volume in circulation of an emergency as in accidents. • Saline solution is used when large amount of sodium has been lost by vomiting or by gastric or intestinal duodenal aspiration or through analimucation fistuala. • Dextrose monohydrate is used as supplement to cow's milk in part of feeding. • Hypertonic dextrose solution (25-50%) is in medical treatment partly because they are believed to strengthen heart muscles. • Hypertonic solutions are used in intravenous injection to relieve intractable pressure in patient with hydrocephalus and meningitis. Market Survey Our system of medicine like Ayurveda were well established and schools and hospitals with treatises and instruction manuals were in wide use. The growth of I.V. fluid manufacturing was faster than the growth rate of drugs. I.V fluids are the solutions applied directly to the vein of a patient who suffer from the weaknesses due to the deficiency of body fluids. These IV fluids are the best alternative which can yield sudden result in the health of a patient by replenishing the body fluids. Liquid glucose and dextrose are being produced in the organized sector. Glucose is produced in solid as well as in liquid form and dextrose is in anhydrous and monohydrous form. The gap between the production and consumption of liquid glucose is removed by the import. I.V. fluid demand is normally linked to the number of hospital beds. Observations show that 18 bottles of I.V. fluids are consumed per bed per month in the country. The demand is estimated to increase at a rate of 9 to 12% per annum. The present demand level is estimated to be around 2200 lakh bottles per annum. Areas with high population density and average temperatures are major consumption areas of I.V. fluids. Demand is high Uttar Pradesh, Rajasthan, Haryana, Bihar, Madhya Pradesh and West Bengal. North India alone account for one third of the total demand in the country.
Plant capacity: 48000 Bottles/day(500 ml)Plant & machinery: 253 Lakhs
Working capital: -T.C.I: Cost of Project: 834 Lakhs
Return: 29.00%Break even: 52.00%
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I.V. FLUID - Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities, Cost and Revenue, Plant Economics

Intravenous fluids are fluids which are intended to be administered to a patient intravenously, directly through the circulatory system. These fluids must be sterile to protect patients from injury, and there are a number of different types available for use. Fluids are given when someone's body fluid volume falls. There are a number of things which can cause a drop in fluid volume. Vomiting and diarrhea are a classic example, which is why people are encouraged to drink fluids when they are sick, to keep their fluid volume stable. Another cause is blood loss, which causes problems both because people lose blood products, and because they experience a loss in fluid volume. Electrolyte levels in the blood can also become unstable as a result of rapid changes in fluid volume, in which case intravenous fluids can be used to restore the balance. Intravenous fluids can be broken into two broad groups. Crystalloids such as saline solutions contain a solution of molecules which can dissolve in water. When crystalloids are administered, they tend to create low osmotic pressure, allowing fluid to move across the blood vessels, and this can be linked with edema. Colloids contain particles which are not soluble in water, and they create high osmotic pressure, attracting fluid into the blood vessels. Blood is an example of a commonly administered intravenous colloid. Intravenous fluids can also be used as a route of medication administration. If a doctor wants to deliver a small amount of medication over an extended period of time, it can be dissolved in a bag of intravenous fluids and set on an infusion pump which delivers the medicated fluid directly into the blood. They are also commonly used to assist with surgical recovery; people who receive fluids after surgery tend to experience better recovery than people who do not. There are many solutions are used for IV fluids. The specific one used depends on the situation. Many other compounds can be added to the IV solution as a simple means of administration. For example, antibiotics, pain killers and so on can be added to the IV so the patient receives the drug at a constant rate over a long period of time. The basic function of IV fluids is to replenish the body fluids. Although there are a number of IV fluids but generally three types of IV fluids are used in hospitals as IV drips. They are as follows: 1. Dextrose injection fluid 2. Dextrose and sodium chloride injection fluid 3. Sodium chloride injection solution (Saline solution). When saline is injected intravenously, it compensate the deficiency of sodium ions when dextrose is injected it gives energy due to glucose content of it when dextro-saline is given in combination, it replenishes the dehydration as well as gives energy thereby recouping debility syndrome and also in general take care of malaise. Uses There are four main ranges of application of highly specialized intravenous infusion solutions: 1. Treatment of discarded water and electrolyte metabolism, especially in severe cases. 2. Therapy of acid base in balances. 3. The volume substitution and volume replacement in surgery of accident victim suffering blood loss. 4. Paratral nutrition for severally ill and post-operative patients. 5. Aqueous isotonic injection (5%) of dextrose is given as intravenous injections to increase the column of circulating blood in the shocks and haemarrhages and to counteract dehydration. When it is desired to replace excessive salt loss also glucose is injected along with sodium chloride. 6. Dextrose solution is used during postoperative period when sodium extraction is reduced. 7. Dextrose solution with concentration of 10-15% is used as diuretic for increase in urine flow. 8. Dextrose solutions of 5% normal salinic are used for restoring fluid volume in circulation of an emergency as in accidents with haemarrhage. Saline solution is used when large amount of sodium has been lost by vomiting or by gastric or intestinal duodenal aspiration or through an alimentary fistula. 9. Dextrose monohydrate is used as supplement to cow's milk in part of feeding. 10. Hypertonic dextrose solution (25-50%) is in medical treatment partly because they are believed to strengthen heart muscles. Hypertonic solutions are used in intravenous injection to relieve intractable pressure in-patient with hydrocephalus and meningitis. Market Survey India's traditions in the science of health and healing go back to the halcyon days of Surushta, Vagbhatta and Charaka. Our system of medicine like Ayurveda were well established and schools and hospitals with treatises and instruction manuals were in wide use. The establishment of modern pharmaceutical industry in India may be said to have commercial with the selling up of Bengal chemicals by acharya P.C Ray in Kolkata and of Alembic Chemical in B.D Amin. The growth of I.V. fluid manufacturing was faster than the growth rate of drugs. I.V fluids are the solutions applied directly to the vein of a patient who suffer from the weaknesses due to the deficiency of body fluids. These IV fluids are the best alternative which can yield sudden result in the health of a patient by replanishing the body fluids. Liquid glucose and dextrose are being produced in the organized sector. Glucose is produced in solid as well as in liquid form and dextrose is in anhydrous and monohydros form. The installed capacity, production and capacity utilization of liquid glucose are indicated below. I.V. fluid demand is normally linked to the number of hospital beds. Observations show that 18 bottles of I.V. fluids are consumed per bed per month in the country. The demand is estimated to increase at a rate of 9 to 12% per annum. The present demand level is estimated to be around 2200 Lakh bottles per annum. Areas with high population density and average temperatures are major consumption areas of I.V. fluids. Demand is high Uttar Pradesh, Rajasthan, Haryana, Bihar, Madhya Pradesh and West Bengal. North India alone account for one third of the total demand in the country. Few Indian Major Players are as under Ahlcon Parenterals (India) Ltd. Core Laboratories Ltd. Gujarat Ambuja Proteins Ltd. Gujarat Inject Ltd. Haffkine Bio-Pharmaceutical Corpn. Ltd. India Infusion Ltd. Indian Maize & Chemicals Ltd. K G Gluco Biols Ltd. Kamala Sugar Mills Ltd. Kokad Pharmaceutical Laboratories Ltd. Marck Biosciences Ltd. Origin Agrostar Ltd. Parenteral Surgicals Ltd. Senbo Industries Ltd. Span Medicals Ltd. Tirupati Starch & Chemicals Ltd. Unique Sugars Ltd. Wockhardt Health Care Ltd.
Plant capacity: 144,00,000 Bottles/AnnumPlant & machinery: Rs. 808 Lakhs
Working capital: -T.C.I: Cost of Project: Rs 1367 Lakhs
Return: 26.00%Break even: 46.00%
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Saline and Dextrose Fluid (IV Fluid) BFS Technology

As part of the millennium development goals (MDGs), governments in the region have developed strategies directed at reducing the negative impact of diseases like HIV, Malaria or Tuberculosis on the society by 2015. The strategies include halting and reversing the spread of HIV/AIDS, reducing the level of malaria infection, and reducing prevalence and death rates associated with tuberculosis. Severe malaria results into high fever, which requires the use of Intravenous Fluids as the first line of treatment. However, due to limited local production and supply, the fluids are comparatively expensive compared to other developed world where they are affordable and readily available. In India, local monopolies and distributors that sell the fluids very costly import 98% of the IV Fluids. Faced with the current factual situation Govt. Oriented organization planned to establish Intravenous Project to locally produce and supply this very essential product to the healthcare sector as a noble contribution in improving healthcare services. The project expects to promote the common good in the Eastern Region, to reduce the current high level of deaths from 9-14% of in-patient visits in hospitals and health facilities. In medicine, saline (also saline solution) is a general phrase referring to a sterile solution of sodium chloride (NaCl, more commonly known as salt) in water, but is only sterile when it is to be placed parenterally (such as intravenously); otherwise, a saline solution is a salt water solution. The sterile solution is typically used for intravenous infusion, rinsing contact lenses, nasal irrigation, and often used to clean a new piercing. It is also a good medium to store an avulsed ("knocked out") tooth until it can be re-implanted by a dentist. Saline solutions are available in various formulations for different purposes. Salines are also used in cell biology, molecular biology, and biochemistry experiments. Uses & Applications There are four main ranges of application of highly specialized intravenous infusion solutions: • Treatment of discarded water and electrolyte metabolism, especially in severe cases. • Therapy of acid base in balances. • The volume substitution and volume replacement in surgery of accident victim suffering blood lose. • Paratrial nutrition for severally ill and post-operative patients. • Aqueous isotonic injection (5%) of dextrose is given as intravenous injections to increase the column of circulating blood in the shocks and hemorrhages and to counteract dehydration. Dextrose solution is used during post operative period when sodium extraction is reduced. • Dextrose solution with concentration of 10-15% is used as diuretic for increase in urine flow. • Dextrose solution of 5% normal salmic is used for restarting fluid volume in circulation of an emergency as in accidents. • Saline solution is used when large amount of sodium has been lost by vomiting or by gastric or intestinal duodenal aspiration or through analimucation fistuala. • Dextrose monohydrate is used as supplement to cow's milk in part of feeding. • Hypertonic dextrose solution (25-50%) is in medical treatment partly because they are believed to strengthen heart muscles. • Hypertonic solutions are used in intravenous injection to relieve intractable pressure in patient with hydrocephalus and meningitis. Market Survey Our system of medicine like Ayurveda were well established and schools and hospitals with treatises and instruction manuals were in wide use. The growth of I.V. fluid manufacturing was faster than the growth rate of drugs. I.V fluids are the solutions applied directly to the vein of a patient who suffer from the weaknesses due to the deficiency of body fluids. These IV fluids are the best alternative which can yield sudden result in the health of a patient by replenishing the body fluids. Liquid glucose and dextrose are being produced in the organized sector. Glucose is produced in solid as well as in liquid form and dextrose is in anhydrous and monohydrous form. The gap between the production and consumption of liquid glucose is removed by the import. I.V. fluid demand is normally linked to the number of hospital beds. Observations show that 18 bottles of I.V. fluids are consumed per bed per month in the country. The demand is estimated to increase at a rate of 9 to 12% per annum. The present demand level is estimated to be around 2200 lakh bottles per annum. Areas with high population density and average temperatures are major consumption areas of I.V. fluids. Demand is high Uttar Pradesh, Rajasthan, Haryana, Bihar, Madhya Pradesh and West Bengal. North India alone account for one third of the total demand in the country.
Plant capacity: 48000 Bottles/day(500 ml)Plant & machinery: 253 Lakhs
Working capital: -T.C.I: Cost of Project: 834 Lakhs
Return: 29.00%Break even: 52.00%
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I.V. Fluid - Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities, Cost and Revenue, Plant Economics

Intravenous fluids are fluids which are intended to be administered to a patient intravenously, directly through the circulatory system. Fluids are given when someone's body fluid volume falls. Liquid glucose and dextrose are being produced in the organized sector. I.V. fluid demand is normally linked to the number of hospital beds. Observations show that 18 bottles of I.V. fluids are consumed per bed per month in the country. The demand is estimated to increase at a rate of 9 to 12% per annum. The present demand level is estimated to be around 2200 Lakh bottles per annum. Areas with high population density and average temperatures are major consumption areas of I.V. fluids. Demand is high Uttar Pradesh, Rajasthan, Haryana, Bihar, Madhya Pradesh and West Bengal. North India alone account for one third of the total demand in the country. Few Indian Major Players are as under Ahlcon Parenterals (India) Ltd. Core Laboratories Ltd. Gujarat Ambuja Proteins Ltd. Gujarat Inject Ltd. Haffkine Bio-Pharmaceutical Corpn. Ltd. India Infusion Ltd. Indian Maize & Chemicals Ltd. K G Gluco Biols Ltd. Kamala Sugar Mills Ltd. Kokad Pharmaceutical Laboratories Ltd. Marck Biosciences Ltd. Origin Agrostar Ltd. Parenteral Surgicals Ltd. Senbo Industries Ltd. Span Medicals Ltd. Tirupati Starch & Chemicals Ltd. Unique Sugars Ltd. Wockhardt Health Care Ltd.
Plant capacity: 144,00,000 Bottles/AnnumPlant & machinery: Rs. 808 Lakhs
Working capital: -T.C.I: Cost of Project: Rs 1367 Lakhs
Return: 26.00%Break even: 46.00%
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