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IV Fluids, I.V. solutions, Intravenous fluids, Normal Saline (NS, 0.9NaCl, or NSS), Lactated Ringers (LR, Ringers Lactate, or RL), Dextrose 5%, Normal Saline (Half Normal Saline, 0.45NaCl, .45NS), IV Fluids & Dialysis products - LVP/SVP Volume Parenteral

 

I V Fluids

Intravenous therapy (IV) is therapy that delivers fluids directly into a vein. The intravenous route of administration can be used both for injections, using a syringe at higher pressures; as well as for infusions, typically using only the pressure supplied by gravity. Intravenous infusions are commonly referred to as drips.

The intravenous route is the fastest way to deliver medications and fluid replacement throughout the body, because they are introduced directly into the circulation. Intravenous therapy may be used for fluid volume replacement, to correct electrolyte imbalances, to deliver medications, and for blood transfusions.

Infusion therapy as a basic toll of modern medical care enables the physician to restore and stabilize homeostasis states quickly and completely. In nursing homes and hospital where patients are suffering from acute dehydration or considerable debilitating conditions, the intra venous fluids are used as I.V. drips. The basic function of I.V. fluids is to replenish the body fluids. Although there are number of I.V. fluids, but generally three types of I.V. fluids are used in hospitals as I.V. drips. 1. Dextrose injection fluid. 2. Dextrose and sodium chloride injection fluid. 3. Sodium Chloride injection solution (Saline solution). Dextrose solution is used during postoperative period when sodium extraction of 10-15% are used as diuretic for increasing in urine flow. Saline solution is used when large amount of sodium has been lost by vomiting or by gastric or intestinal duodenal aspiration or through an alimentary fistula. Dextrose monohydrate is used as supplement to cow’s milk in part of feeding. Hypertonic dextrose solution (25-50%) is in medical treatment partly because they are believed to strengthen heart muscles. Hypertonic solutions are used in intravenous injection to relieve intractable pressure in-patient with hydrocephalus and meningitis. The drug industry has now achieved an impressive growth during the last four decades of planning and development. These I.V. fluids are the best alternative, which can yield sudden result in the health of a Patient by replenishing the body fluids.

Intravenous solutions have evolved with technologies and designs improving their overall functionalities. There are several combinations of packaged intravenous products that have come up in recent years. Manufacturers are introducing IV fluids and compounds that can be mixed with other liquid medicines and solutions for IV administration. The aforementioned factors will continue to drive the global intravenous (IV) solution market.  Some of the factors that are having positive impact on the growth of the intravenous (IV) solution market include increased prevalence of chronic disorders and growing popularity of IV led treatments and therapies intended towards curing cance.

Uses and Applications

There are main ranges of application of highly specialized intravenous infusion solutions:

• Treatment of discarded water and electrolyte metabolism, especially in severe cases.

• Therapy of acid base in balances.

• The volume substitution and volume replacement in surgery of accident victim suffering blood loss.

• Paratral nutrition for severally ill and post-operative patients.

Aqueous isotonic injection (5%) of dextrose is given as intravenous injections to increase the column of circulating blood in the shocks and hemorrhages and to counteract dehydration. When it is desired to replace excessive salt loss also glucose is injected along with sodium chloride. Intravenous fluids can also be used as a route of medication administration. If a doctor wants to delI.V.er a small amount of medication over an extended period of time, it can be dissolved in a bag of intravenous fluids and set on an infusion pump which delivers the medicated fluid directly into the blood.

They are also commonly used to assist with surgical recovery; people who receive fluids after surgery tend to experience better recovery than people who do not.

Global Intravenous Solutions Market Trends:

Over the past few years, the prevalence of hectic work schedules and unhealthy lifestyles has increased across the globe. The consequent decline in physical activity and proper nutrition has led to a rise in the incidences of chronic diseases, which in turn has boosted the demand for intravenous solutions. Besides, there has been significant growth in the production of IV fluids, particularly in developed countries. For instance, it was reported that due to the shortage of IV saline, the US Food and Drug Administration (FDA) and other market. The intravenous fluid bags market size will grow at a CAGR of 6% at an incremental growth of $ 667.51 MN during 2020-2024.

The increasing prevalence of chronic diseases such as the rise of cholera and growing acceptance of vitamin c intravenous for colorectal cancer are the major drivers propelling market growth. However, the presence of stringent government regulations, rising continuous demand for IV solutions in the US, and increasing vitamin C intravenous therapy prices constrain the growth of the market.

The rising number of surgeries, the need for a faster route of drug administration, growing preference for single-dose administration of vaccines and drugs, and an increase in local manufacturing is expected to drive the market for LVP. Parenteral route of administration helps provide an accurate dose of medication as the majority of the drug is directly absorbed in circulation, bypassing the gastrointestinal tract.

The drug serum level increases rapidly through parenteral administration. For instance, postoperative parenteral nutrition induces a substantial increase in serum leptin within six hours and helps reach a rise of more than four folds within 14 hours. Moreover, parenteral administration of ascorbate (Vitamin C) decreases the growth rate of murine hepatoma. However, oral administration of the same dosage does not exhibit similar anti-tumoral effects.

Advantages of BFS Technology:

Blow-fill-seal technology enables the manufacture of preservative-free single-unit doses. PreservatI.V.es are recognized as potentially harmful to the sensitive mucosae of the eyes, nose, and lungs, so this is an enormous benefit to sensitive patients. Another advantage of unit-doses is that they ensure that the patient takes the correct amount of product, especially when dealing with highly potent compounds, i.e. those therapeutically active at a low concentration.

Sterile unit-doses are portable and easy to use individually, excellent properties for today’s active lifestyles. Blow-fill-seal (BFS) single doses are an ideal solution for use in ophthalmology, respiratory diseases, rhinology, and antisepsis and wound care. Blow-fill-seal technology reduces personnel intervention making it a more robust method for the aseptic preparation of sterile pharmaceuticals. BFS is used for the filling of vials for parenteral preparations and infusions, eye drops, and inhalation products. Generally the plastic containers are made up of polyethylene and polypropylene. Polypropylene is more commonly used to form containers which are further sterilized by autoclaving as polypropylene has greater thermo stability.

Blow Fill and Seal technology is mainly used for pharmaceutical solutions. The examples of pharmaceutical solutions that can be packaged are injectable solutions, antibiotics, ophthalmological drops, suspensions, infusion solutions, solutions for dialysis, solutions for irrigation and solutions for hemofiltration. The basic concept of BFS is that a container is formed, filled, and sealed in a continuous process without human intervention, in a sterile enclosed area inside a machine. Thus this technology can be used to aseptically manufacture sterile pharmaceutical liquid dosage forms.

The process is multi-stepped: first, pharmaceutical-grade plastic resin is vertically heat extruded through a circular throat to form a hanging tube called the parison. This extruded tube is then enclosed within a two-part mould, and the tube is cut above the mould. The mould is transferred to the filling zone, or sterile filling space, where filling needles (mandrels) are lowered and used to inflate the plastic to form the container within the mould. Following the formation of the container, the mandrel is used to fill the container with liquid. Following filling the mandrels are retracted and a secondary top mould seals the container. All actions take place inside a sterile shrouded chamber inside the machine. The product is then discharged to a non-sterile area for labeling, packaging and distribution. The process begins with the Extrusion of plastic granules in the form of a hot hollow pipe of molten plastic called a parison.

The following step is the Blow molding of the container from the plastic granule. The parison is closed between the mould, and the container gets formed either by blowing sterile compressed air or by vacuum or by using vacuum as well as blowing. The container assumes the shape of the cavity in the mould. The container thus produced is open from the top and in its top part, the plastic is still hot and in molten state until the subsequent steps of filling and container sealing.

Features:

1. 100% film utilization: No waste edge between bags, reducing both material and energy consumption.

2. Special I.V. bag design: each bag saves 10mm film than others.

3. Reliable heating and welding system: Leakage rate less than 0.03%.

4. Quick changeover: 0.5-1 hour to switch from one size to another.

5. Stable transmission system: only needs 1 control system, 1 HMI and 1 operator.

6. Safe filling nozzle: No solution overflows, no particles generation.

7. Auto faulty rejection system detected by the machine.

8. Production line length is reduced by 1/3, both workshop and air conditioning and cleaning area are reduced by 1/3, greatly reducing the initial investment and future running cost.

9. Simple structure, more stable and reliable performance.

 

 

 

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Saline and Dextrose Fluid (IV) - Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities, Cost and Revenue

The growth of I.V. fluid manufacturing was faster than the growth rate of drugs. These IV fluids are the best alternative which can yield sudden result in the health of a patient by replenishing the body fluids. Liquid glucose and dextrose are being produced in the organized sector. The gap between the production and consumption of liquid glucose is removed by the import. I.V. fluid demand is normally linked to the number of hospital beds. Observations show that 18 bottles of I.V. fluids are consumed per bed per month in the country. The demand is estimated to increase at a rate of 9 to 12% per annum. The present demand level is estimated to be around 2200 lakh bottles per annum. Demand is high Uttar Pradesh, Rajasthan, Haryana, Bihar, Madhya Pradesh and West Bengal. North India alone account for one third of the total demand in the country.
Plant capacity: -Plant & machinery: -
Working capital: -T.C.I: -
Return: 1.00%Break even: 1.00%
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IV (intravenous) Fluids [Form Fill Seal (FFS) Technology] - Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Plant Layout

Intravenous fluids are fluids which are intended to be administered to a patient intravenously, directly through the circulatory system. These fluids must be sterile to protect patients from injury, and there are a number of different types available for use. Many companies manufacture packaged intravenous fluids, as well as products which can be mixed with sterile water to prepare a solution for intravenous administration. Intravenous fluids can be broken into two broad groups. Crystalloids such as saline solutions contain a solution of molecules which can dissolve in water. When crystalloids are administered, they tend to create low osmotic pressure, allowing fluid to move across the blood vessels, and this can be linked with edema. Colloids contain particles which are not soluble in water, and they create high osmotic pressure, attracting fluid into the blood vessels. Blood is an example of a commonly administered intravenous colloid. I.V. fluid demand is normally linked to the number of hospital beds. Observations show that 18 bottles of I.V. fluids are consumed per bed per month in the country. The demand is estimated to increase at a rate of 9 to 12% per annum. The present demand level is estimated to be around 2200 Lakh bottles per annum. Areas with high population density and average temperatures are major consumption areas of I.V. fluids. Demand is high Uttar Pradesh, Rajasthan, Haryana, Bihar, Madhya Pradesh and West Bengal. North India alone account for one third of the total demand in the country. So any new entrants can venture in to this industry. Few Indian Major Players are as under:- Ahlcon Parenterals (India) Ltd. Core Laboratories Ltd. Gujarat Ambuja Proteins Ltd. Gujarat Inject Ltd. Haffkine Bio-Pharmaceutical Corpn. Ltd. India Infusion Ltd. Indian Maize & Chemicals Ltd. K G Gluco Biols Ltd. Kamala Sugar Mills Ltd. Kokad Pharmaceutical Laboratories Ltd. Marck Biosciences Ltd. Origin Agrostar Ltd. Parenteral Surgicals Ltd. Senbo Industries Ltd. Span Medicals Ltd. Tirupati Starch & Chemicals Ltd. Unique Sugars Ltd. Wockhardt Health Care Ltd.
Plant capacity: 144 Lakh Bottles/AnnumPlant & machinery: Rs. 808 Lakhs
Working capital: -T.C.I: Cost of Project : Rs. 1367 Lakhs
Return: 25.00%Break even: 46.00%
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IV Fluid and Dialysis Solution - Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities, Cost and Revenue

Intravenous therapy IV therapy is the infusion of liquid substances directly into a vein. Intravenous simply means "within vein". Therapies administered intravenously are often called specialty pharmaceuticals. Compared with other routes of administration, the intravenous route is the fastest way to deliver fluids and medications throughout the body. The bioavailability of the medication is 100% in IV therapy. The majority of an IV solution is sterile water. Chemically, water is referred to as a “solvent.” A solvent is a substance that dissolves other materials called “solutes.” Within IV solutions, the solutes can be molecules called electrolytes (charged particles such as sodium, potassium, and chloride) and/or other larger compounds such as proteins or molecules. Patient needs IV fluid therapy for maintenance (to supply daily needs), replacement (to replace deficit and on-going losses) and resuscitation (to correct an intravascular or extracellular deficit). Therefore, it is a good project for entrepreneurs to invest. Few Indian Major Players are as under • Ahlcon Parenterals (India) Ltd. • Amanta Healthcare Ltd. • Goa Formulations Ltd. • Kokad Pharmaceutical Laboratories Ltd. • Parenteral Surgicals Ltd. • Punjab Formulations Ltd. • Senbo Industries Ltd. •Shree Krishna Keshav Laboratories Ltd. •Span Medicals Ltd. •Wockhardt Health Care Ltd.
Plant capacity: IV Fluid NS5 (500 ml Size):8,000 Bottles/Day •IV Fluid DNS (500 ml Size): 8,000 Bottles/Day •IV Fluid RL (500 ml Size): 8,000 Bottles/Day •IV Fluid D5 (500 ml Size): 8,000 Bottles/Day •IV Fluid D10 (500 ml Size): 4,000 Bottles/Day •Dialysis Solution (1000Plant & machinery: Rs 315 Lakhs
Working capital: -T.C.I: Cost of Project :Rs 1151 Lakhs
Return: 28.41%Break even: 43.11%
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I.V. FLUID (Automatic Plant)

Intravenous fluids are fluids which are intended to be administered to a patient intravenously, directly through the circulatory system. These fluids must be sterile to protect patients from injury, and there are a number of different types available for use. Many companies manufacture packaged intravenous fluids, as well as products which can be mixed with sterile water to prepare a solution for intravenousadministration. I.V. fluids or Intravenous fluids are life saving drugs, which are widely used in surgery, pediatrics, urology, obstetrics and gynecology. They are given mostly to patients suffering from dehydration, diarrhorea, vomiting, gastroenteritis and excessive perspiration. The growth of the global intravenous solutions market is driven by several factors. The increasing incidence of gastrointestinal disorders, diabetes, and cancer is one of the major factors that are expected to increase the rate of adoption of intravenous solutions among consumers. Thus, due to demand it is a good project for entrepreneurs to invest. Few Indian Major Players are as under • AxaParenterals Ltd. • D.J. Laboratories Pvt. Ltd. • Baxter International Inc. • Amanta Healthcare • Aishwarya Healthcare
Plant capacity: 1,44,00,000 bottles/annumPlant & machinery: Rs 462 lakhs
Working capital: -T.C.I: Cost of Project : Rs 1362lakhs
Return: 27.00%Break even: 66.00%
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I.V. Fluids

Intravenous fluids are fluids which are intended to be administered to a patient intravenously, directly through the circulatory system. These fluids must be sterile to protect patients from injury, and there are a number of different types available for use. Many companies manufacture packaged intravenous fluids, as well as products which can be mixed with sterile water to prepare a solution for intravenousadministration. I.V. fluids or Intravenous fluids are life saving drugs, which are widely used in surgery, pediatrics, urology, obstetrics and gynecology. They are given mostly to patients suffering from dehydration, diarrhoea, vomiting, gastroenteritis and excessive perspiration. The growth of the global intravenous solutions market is driven by several factors. The increasing incidence of gastrointestinal disorders, diabetes, and cancer is one of the major factors that are expected to increase the rate of adoption of intravenous solutions among consumers. Thus, due to demand it is a good project for entrepreneurs to invest. Few Indian Major Players are as under • AxaParenterals Ltd. • D.J. Laboratories Pvt. Ltd. • Baxter International Inc. • Amanta Healthcare • Aishwarya Healthcare
Plant capacity: I.V. Fluid (500 ml.):14,400,000 Bottles/annumPlant & machinery: Rs 476 lakhs
Working capital: -T.C.I: Cost of Project: Rs 1092 lakhs
Return: 26.00%Break even: 53.00%
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IV Fluids

Intravenous fluids are fluids which are intended to be administered to a patient intravenously, directly through the circulatory system. These fluids must be sterile to protect patients from injury, and there are a number of different types available for use.Fluids are given when someone's body fluid volume falls. There are a number of things which can cause a drop in fluid volume. Vomiting and diarrhea are a classic example, which is why people are encouraged to drink fluids when they are sick, to keep their fluid volume stable.. When crystalloids are administered, they tend to create low osmotic pressure, allowing fluid to move across the blood vessels, and this can be linked with edema.Intravenous fluids can be broken into two broad groups. Crystalloids such as saline solutions contain a solution of molecules which can dissolve in water.The specific one used depends on the situation. Many other compounds can be added to the IV solution as a simple means of administration. For example, antibiotics, pain killers and so on can be added to the IV so the patient receives the drug at a constant rate over a long period of time. The Indian pharmaceutical industry is the fourth largest in the world in terms of volume of output and thirteenth in domestic demand. However, the Indian industry, valued at USD 17 bn in represented just over 1% of the global pharmaceutical industry (USD 1700 bn) in value terms. The domestic market is estimated at Rs 680 bn. The Indian manufacturing sector with an average annual growth rate of about 14% during the quinquennium 2002-2007. It is projected to grow at an average annual rate exceeding 15% during 2007-2010 and is likely to reach the level of about USD 23 to 28 bn in 2010. Parenteral Drugs India Ltd (PDIL) is the leading IV fluid producer in India with a capacity of 33 crore bottles a year and a market share of over 25 per cent. Entrepreneurs who invest in this project will be successful. Few Indian major players are as under • Abaris Healthcare Pvt. Ltd. • AhlconParenterals (India) Ltd. • AxaParenterals Ltd. • Infutec Healthcare Ltd. • Kokad Pharmaceutical Laboratories Ltd. • Parenteral Surgicals Ltd.
Plant capacity: 27,000,000 Bottles/annumPlant & machinery: 476 lakhs
Working capital: -T.C.I: Cost of Project: Rs1060 lakhs
Return: 26.00%Break even: 53.00%
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IV Fluids (BFS Technology)

Intravenous fluids are fluids which are intended to be administered to a patient intravenously, directly through the circulatory system. These fluids must be sterile to protect patients from injury, and there are a number of different types available for use. Many companies manufacture packaged intravenous fluids, as well as products which can be mixed with sterile water to prepare a solution for intravenous administration. Fluids are given when someone's body fluid volume falls. There are a number of things which can cause a drop in fluid volume. Vomiting and diarrhea are a classic example, which is why people are encouraged to drink fluids when they are sick, to keep their fluid volume stable. Another cause is blood loss, which causes problems both because people lose blood products, and because they experience a loss in fluid volume. Electrolyte levels in the blood can also become unstable as a result of rapid changes in fluid volume, in which case intravenous fluids can be used to restore the balance. India has the world's third largest active pharmaceutical ingredients (API) for the industry valued at a little less than USD 2 bn. Top 5 API producers account for approximately 6.5 %. The leading APIs are anti-infectives, gastrointestinal, cardiovascular and respiratory drugs. The Chemical Pharmaceutical Generic Association (CPA) projects that India's share of the world API market will grow by 10.5% by 2010 as patented blockbuster drugs lose their patent protection. The CPA also expects that the domestic Indian market for APIs, both generic and branded, will rise from USD 755 mn in 2005 to USD 1.9 bn in 2010.
Plant capacity: 48,000 Bottles/Day 500 ml each bottlePlant & machinery: 253 Lakhs
Working capital: N/AT.C.I: Cost of Project: 834 Lakhs
Return: 29.00%Break even: 52.00%
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Production of I.V. Fluids (Saline and Dextrose). Intravenous Solution (IV) Manufacturing Business with Blow-Fill-Seal (BFS) Technology.

Fluids are given when someone's body fluid volume falls. There are a number of things which can cause a drop in fluid volume. Vomiting and diarrhea are a classic example, which is why people are encouraged to drink fluids when they are sick, to keep their fluid volume stable. Another cause is blood loss, which causes problems both because people lose blood products, and because they experience a loss in fluid volume. Electrolyte levels in the blood can also become unstable as a result of rapid changes in fluid volume, in which case intravenous fluids can be used to restore the balance. Intravenous fluids are fluids which are intended to be administered to a patient intravenously, directly through the circulatory system. These fluids must be sterile to protect patients from injury, and there are a number of different types available for use. Many companies manufacture packaged intravenous fluids, as well as products which can be mixed with sterile water to prepare a solution for intravenous administration. Intravenous fluids can be broken into two broad groups. Crystalloids such as saline solutions contain a solution of molecules which can dissolve in water. When crystalloids are administered, they tend to create low osmotic pressure, allowing fluid to move across the blood vessels, and this can be linked with edema. Colloids contain particles which are not soluble in water, and they create high osmotic pressure, attracting fluid into the blood vessels. Blood is an example of a commonly administered intravenous colloid. Infusion therapy as a basic toll of modern medical care enables the physician to restore and stabilize homeostasis states quickly and completely. In nursing homes and hospital where patients are suffering from acute dehydration or considerable debilitating conditions, the intra venous fluids are used as I.V. drips. The basic function of I.V. fluids is to replenish the body fluids. Although there are a number of I.V. fluids but generally three types of I.V. fluids are used in hospitals as I.V. drips. Uses and Applications There are main ranges of application of highly specialized intravenous infusion solutions: • Treatment of discarded water and electrolyte metabolism, especially in severe cases. • Therapy of acid base in balances. • The volume substitution and volume replacement in surgery of accident victim suffering blood loss. • Paratral nutrition for severally ill and post-operative patients. • Aqueous isotonic injection (5%) of dextrose is given as intravenous injections to increase the column of circulating blood in the shocks and haemorrhages and to counteract dehydration. When it is desired to replace excessive salt loss also glucose is injected along with sodium chloride. Intravenous fluids can also be used as a route of medication administration. If a doctor wants to delI.V.er a small amount of medication over an extended period of time, it can be dissolved in a bag of intravenous fluids and set on an infusion pump which delivers the medicated fluid directly into the blood. They are also commonly used to assist with surgical recovery; people who receive fluids after surgery tend to experience better recovery than people who do not. Intravenous Fluids Market is expected to witness growth of international market with respect to advancements and innovations including development history, competitive analysis and regional development forecast. The growth of the global intravenous solutions market is driven by several factors. The increasing incidence of gastrointestinal disorders, diabetes, and cancer is one of the major factors that are expected to increase the rate of adoption of intravenous solutions among consumers. The rising popularity of intravenous vitamin C therapy in cancer treatment is one of the major trends in the intravenous solutions market. The intravenous vitamin C solution has been observed to have an increased toxicity to cancer cells and improve the patients' quality of life. Intravenous fluids are extensively used to treat electrolyte imbalances, maintain fluid balance, and replace fluid losses. These fluids are dispensed in volumes ranging from 25-1,000 milliliters and are available in either plastic bags or glass bottles. A complete mixture of all essential nutrients is also available in multi-chamber bags, and these bags are gaining immense popularity among numerous end-users. The global Intravenous (I.V.) solutions market was valued at USD 6.9 billion in 2015 and is projected to grow at a CAGR of 7.8% over the forecast period. The emergence of this market is attributed to the fast growing geriatric population and prevalence of malnutrition in the elderly and pediatric population. Blow-Fill-Seal (BFS) Technology In blow-fill-seal (BFS) technology, which is a form of advanced aseptic manufacturing, the container is formed, filled, and sealed in one continuous, automated system. A primary advantage of this technology is reducing human intervention, which reduces the risk of microbial contamination and foreign particulates. BFS has long been used in liquid pharmaceutical applications, including small containers, such as ophthalmic and respiratory drug ampoules, as well as larger volume containers, such as saline or dextrose solutions. More recently, BFS technology has been expanding into injectable and into biologics, including vaccines and monoclonal antibodies (mAbs). Advantages of BFS Technology: • Blow-fill-seal technology enables the manufacture of preservative-free single-unit doses. PreservatI.V.es are recognized as potentially harmful to the sensitive mucosae of the eyes, nose, and lungs, so this is an enormous benefit to sensitive patients. • Another advantage of unit-doses is that they ensure that the patient takes the correct amount of product, especially when dealing with highly potent compounds, i.e. those therapeutically active at a low concentration. • Sterile unit-doses are portable and easy to use individually, excellent properties for today’s active lifestyles. Blow-fill-seal (BFS) single doses are an ideal solution for use in ophthalmology, respiratory diseases, rhinology, antisepsis and wound care. • Blow-fill-seal technology reduces personnel intervention making it a more robust method for the aseptic preparation of sterile pharmaceuticals. BFS is used for the filling of vials for parenteral preparations and infusions, eye drops, and inhalation products. Generally the plastic containers are made up of polyethylene and polypropylene. Polypropylene is more commonly used to form containers which are further sterilised by autoclaving as polypropylene has greater thermostability. • Blow Fill and Seal technology is mainly used for pharmaceutical solutions. The examples of pharmaceutical solutions that can be packaged are injectable solutions, antibiotics, ophthalmological drops, suspensions, infusion solutions, solutions for dialysis, solutions for irrigation and solutions for hemofiltration. The basic concept of BFS is that a container is formed, filled, and sealed in a continuous process without human intervention, in a sterile enclosed area inside a machine. Thus this technology can be used to aseptically manufacture sterile pharmaceutical liquid dosage forms. The process is multi-stepped: first, pharmaceutical-grade plastic resin is vertically heat extruded through a circular throat to form a hanging tube called the parison. This extruded tube is then enclosed within a two-part mould, and the tube is cut above the mould. The mould is transferred to the filling zone, or sterile filling space, where filling needles (mandrels) are lowered and used to inflate the plastic to form the container within the mould. Following the formation of the container, the mandrel is used to fill the container with liquid. Following filling the mandrels are retracted and a secondary top mould seals the container. All actions take place inside a sterile shrouded chamber inside the machine. The product is then discharged to a non-sterile area for labeling, packaging and distribution. The process begins with the Extrusion of plastic granules in the form of a hot hollow pipe of molten plastic called a parison. The following step is the Blow moulding of the container from the plastic granule. The parison is closed between the mould, and the container gets formed either by blowing sterile compressed air or by vacuum or by using vacuum as well as blowing. The container assumes the shape of the cavity in the mould. The container thus produced is open from the top and in its top part, the plastic is still hot and in molten state until the subsequent steps of filling and container sealing. The subsequent step is filling of the formed container from the top, which is still open (and still in a “hot molten” state). Filling nozzles enter from the top of container and filling is done. Filling nozzles are specially designed and constructed to facilitate automatic cleaning and automatic sterilization. Additional functions of filling nozzles are to blow the bottles and also to provide an exhaust path for air in the container. The filling process can be carried out under a shower of sterile filtered air to avoid contamination during filling. The blower on the sterile air shower can have variable pressure which can be made to change automatically so as to maintain constant air pressure under various situations. The sterile air shower is validated at certain air pressure, and an automatic device can maintain the same pressure by automatically modulating the speed of the blower. The next step is sealing the top of the container, which is still open and in a hot molten state. The top gets pressed between head moulds and as a consequence, the top part of the container gets formed, sealed and at the same time, gets cooled. The result is a hermetically sealed container. The final steps are for De-flashing to remove the flash or scrap, trimming the containers and delivering the containers outside the machine. The whole process of extrusion, blowing, filling, sealing and removing scrap takes between 10 to 18 seconds depending upon the type and size of the container. The advantage of the Blow-Fill-Seal process is derived mainly from the fact that container is formed, quickly filled and sealed under protected environment automatically without human intervention. BFS Machine Professional normal saline I.V. fluids packaging machine is the latest production line with most advanced technology. It can automatically finish film feeding, printing, bag making, filling and sealing in one machine. This BFS line can be used to automatically fill 50-5000ml general solution, special solution, dialysis solution, parenteral nutrition, Antibiotics, Irrigation and Disinfectant solution etc. Features: 1. 100% film utilization: No waste edge between bags, reducing both material and energy consumption. 2. Special I.V. bag design: each bag saves 10mm film than others. 3. Reliable heating and welding system: Leakage rate less than 0.03%. 4. Quick changeover: 0.5-1 hour to switch from one size to another. 5. Stable transmission system: only needs 1 control system, 1 HMI and 1 operator. 6. Safe filling nozzle: No solution overflows, no particles generation. 7. Auto faulty rejection system detected by the machine. 8. Production line length is reduced by 1/3, both workshop and air conditioning and cleaning area are reduced by 1/3, greatly reducing the initial investment and future running cost. 9. Simple structure, more stable and reliable performance. Tags I.V. Fluid Manufacturing Industry, I.V. Fluids Manufacturing Project Report, I.V. Fluids Manufacturing Process, Project Report for I.V. Fluid Plant, I.V. Fluids Manufacturing Equipment, IV Fluids Manufacturing Project Report, I.V. Fluid Manufacturing Plant in India, I.V. Fluids Manufacture, I.V. Fluid Production Plant, I.V. Fluid and Dialysis Solution Manufacturing, Project Report on Dextrose Saline (IV Fluid) Production, I.V. Fluids Production, I.V. Fluid Manufacturing Unit, IV Fluid Manufacturing Business, Pharma Manufacturing Unit in India, Pharmaceutical Company, Intravenous Fluid Production, Project Report on I.V. Fluid, IV Fluid Manufacturing Unit in India, I.V. Fluids Manufacturing Process, I.V. Fluids Manufacturing Equipment, Manufacturing Plant for I.V. Fluid, I.V. Fluid Manufacturing Machine, I.V. Fluids Manufacturing Project Report, IV Fluid Manufacturing Business, Manufacturing Plan of Intravenous Fluid, How to Start I.V. Fluid Production Business, I.V. Solution Manufacturing with BFS Technology, Blow-Fill-Seal Technology, Saline and Dextrose Fluid (IV Fluid) BFS Technology, Blow Fill Seal(BFS) Technology, Project Report on I.V. Fluid (BFS Technology), I.V. Fluid with BFS, Blow-Fill-Seal Machinery, I.V. Fluid Manufacturing using Blow–Fill–Seal Technology, I.V. Fluid Manufacturing project ideas, Projects on Small Scale Industries, Small scale industries projects ideas, IV Fluid Manufacturing Based Small Scale Industries Projects, Project profile on small scale industries, How to Start I.V. Fluid Manufacturing Industry in India, I.V. Fluid Manufacturing Projects, New project profile on I.V. Fluid Manufacturing industries, Project Report on IV Fluid Manufacturing Industry, Detailed Project Report on IV Fluid Manufacturing, Production of Intravenous Sugar Solution (Dextrose Solution), Saline and Dextrose Fluid (iv Fluid) BFS Technology, Production of Intravenous Sugar Solution, Project Report on I.V. Fluid Manufacturing, Pre-Investment Feasibility Study on IV Solution Manufacturing with BFS Technology, Techno-Economic feasibility study on I.V. Solution Manufacturing with BFS Technology, Feasibility report on I.V. Solution Manufacturing with BFS Technology, Free Project Profile on I.V. Solution Manufacturing with BFS Technology, Project profile on I.V. Solution Manufacturing with BFS Technology, Download free project profile on IV Solution Manufacturing with BFS Technology, Industrial Project Report, Project consultant, Project consultancy, Business guidance to clients, Startup Project for I.V. Solution Manufacturing with BFS Technology, Production of I.V. Fluids (Saline and Dextrose), Intravenous Solution (IV) Manufacturing Business with Blow-Fill-Seal (BFS) Technology
Plant capacity: 48,000 Bottles/Day 500 ml each bottlePlant & machinery: 253.00 Lakhs
Working capital: N/AT.C.I: Cost of Project 834.00Lakhs
Return: 29.00%Break even: 52.00%
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I.V. Fluids (BFS Technology)

Intravenous fluids are fluids which are intended to be administered to a patient intravenously, directly through the circulatory system. These fluids must be sterile to protect patients from injury, and there are a number of different types available for use. Fluids are given when someone's body fluid volume falls. There are a number of things which can cause a drop in fluid volume. Vomiting and diarrhea are a classic example, which is why people are encouraged to drink fluids when they are sick, to keep their fluid volume stable. Intravenous fluids can also be used as a route of medication administration. The Indian pharmaceutical industry is the fourth largest in the world in terms of volume of output and thirteenth in domestic demand. However, the Indian industry, valued at USD 17 bn in represented just over 1% of the global pharmaceutical industry (USD 1700 bn) in value terms. The domestic market is estimated at Rs 680 bn. India has the world's third largest active pharmaceutical ingredients (API) for the industry valued at a little less than USD 2 bn. These new business streams would help growth in future earnings. Intravenous (IV) fluids market in India is around Rs. 3,000 crore growing at healthy rate of around 15-20 per cent a year due to its essential requirement in nature. Which facilitates the development of new technologies and ensure a high quality product. Few Indian major players are as under • Abaris Healthcare Pvt. Ltd. • Ahlcon Parenterals (India) Ltd. • Axa Parenterals Ltd. • Infutec Healthcare Ltd. • Kokad Pharmaceutical Laboratories Ltd. • Parenteral Surgicals Ltd. • Punjab Formulations Ltd.
Plant capacity: I.V. Fluid (500 ml.): 48000 Bottles /DayPlant & machinery: Rs 252 lakhs
Working capital: N/AT.C.I: Cost of Project: Rs 833 lakhs
Return: 29.00%Break even: 52.00%
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Maize and It’s by Products Starch, Liquid Glucose, Dextrose, Sorbitol, Maltose, Gluten, Germ and Fiber)

Maize also known as corn is a cereal grain. Maize has become a staple food in many parts of the world, with total production surpassing that of wheat or rice. However, not all of this maize is consumed directly by humans. Some of the maize production is used for corn ethanol, animal feed and other maize products, such as corn starch and corn syrup. Maize is the starch derived from the corn (maize) grain. The starch is obtained from the endosperm of the kernel. D-Soribitol, CH2OH(CHOH)4CH2OH (D-glucitol, L-gulitol), is a hexahydric alcohol with a 6-carbon atom straight-chain that contains six hydroxyl groups, and has a molecular weight of 182.17. The germ, which constitutes 8-14% of the total weight of the corn grain, includes 84-86% of the total oil content of the corn. In India, maize is a kharif crop with harvests and arrivals due only from October onwards. Kharif contributes over 80 per cent of the entire maize output. Bulk of the maize produced in the country goes for production of poultry feed. It is estimated that the demand for maize from the poultry industry would rise by about 6 percent. About twelve states which include Maharashtra, Bihar, Orissa, Uttar Pradesh, Uttarakhand and Delhi account for over 50 percent of the total maize acreage in the country. Increasing demand from Poultry sector is likely to substantially hike maize consumption to go over 30 million tons by 2020. As a whole there is a good scope for new entrepreneur to invest in this business. Few Indian major players are as under • Amaravati Agro Ltd. • Avinash Impex Pvt. Ltd. • Charoen Pokphand Seeds (India) Pvt. Ltd. • Continental Milkose (India) Ltd. • Devi Corn Products Ltd. • Fieldfresh Foods Pvt. Ltd. • Gayatri Bioorganics Ltd.
Plant capacity: Maize Starch: 17520 MT /Annum Sorbitol: 3000 MT/Annum Liquid Glucose: 3000 MT/ Annum Dextrose Monohydrate: 3000 MT/ Annum Dextrose Anhydrous: 1500 MT/ Annum Gluten: 4590 MT/ Annum Maltodextrin: 1500 MT/ Annum GePlant & machinery: 4160 lakhs
Working capital: -T.C.I: Cost of Project: Rs 6928 lakhs
Return: 12.00%Break even: 55.00%
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  • One Lac / Lakh / Lakhs is equivalent to one hundred thousand (100,000)
  • One Crore is equivalent to ten million (10,000,000)
  • T.C.I is Total Capital Investment
  • We can modify the project capacity and project cost as per your requirement.
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  • Caution: The project's cost, capacity and return are subject to change without any notice. Future projects may have different values of project cost, capacity or return.

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