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7-aminocephalosporanic Acid (7-aca) | |
| Cephalosporins, a large group of ?-lactam antibiotics, contain a 7-aminocephalosporanic acid (7-ACA) nucleus which is derived from cephalosporin C, and substitutions of chemical groups or modifications of 7-ACA side-chains resulting in varying pharmacologic properties and antimicrobial activities, development of useful antibiotic agents, also. Cephalosporin C obtained by fungus fermentation can be transformed to 7-ACA by two-step or one step enzymatically conversion process. The most important step in 7-ACA downstream process is represented by its separation from enzymatically produced reaction mixture. Among the used methods new separation techniques have been developed and applied to bioseparations, like reactive extraction and pertraction which have considerable potential. 7-aminocephalosporanic acid is abbreviated as 7-ACA, white or almost white crystalline powder, 7-ACA is an important nucleus in synthesis of cephalosporin antibiotics, in the nucleus 7 and 3 chemical transformation can be used to prepare many cephalosporins: cefazolin sodium, cefotaxime sodium, ceftriaxone sodium, cefoperazone sodium, sodium ceftazidime, cefuroxime sodium. 7-Aminocephalosporanic Acid [chemically, 3-(Acetyloxy-methyl)-7-amino- 8-oxo-5-thia-1- azabicyclo (4.2.0) oct-2-ene-2-carboxylic acid] is the active nucleus for the synthesis of cephalosporins and intermediates. 7-ACA affect the antibacterial activity and can lead to the alteration of pharmacokinetic properties and receptor binding affinity, thus creating new class of cephalosporin antibiotics with important clinical uses. API market based on synthesis is further divided into synthetic API, Biotech API and HPAPI. Synthetic API holds major share in 2018 and is expected to grow at a mid single digit CAGR from 2018 to 2025. The major factors driving the synthetic chemical API market are patent expiration of synthetic (small molecule drugs), increasing number of small molecules in clinical trials, increasing outsourcing by the pharmaceutical companies, CMOs investments to expand manufacturing facilities, rise in incidence of chronic and age-related diseases, rapid growth in oncology market, technological advancement like cryogenic and continuous flow manufacturing. Based on the customer, the synthetic API is further divided into branded API and generic API. Branded API accounted the largest share in 2018 and is expected to grow at a mid single digit CAGR from 2018 to 2025. Generic API is expected to grow at a high single digit CAGR from 2018 to 2025, due to Patent expiry of blockbuster drugs, rising healthcare expenses, increasing outsourcing and shift towards the generic medicines led by the government initiatives. Entrepreneurs who invest in this project will be successful. | |
| Plant capacity: 7-Aminocephalosporanic Acid: 2 MT / Day | Plant & machinery: Rs 1791 lakhs |
| Working capital: - | T.C.I: Cost of Project : Rs 3419 lakhs |
| Return: 28.00% | Break even: 46.00% |
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